DMB and olive oil: New research for health entitled “DMB, Gut Microbiota & Heart Health”

In June 2025, an planetary consortium of scientists led by Professor Emeritus of the International Hellenic University (IHU) and Honorary Member of the American Oil Chemists’ Society (AOCS Fellow – USA) Mr. Apostolos Kiritsakis, published successful the planetary technological diary Journal of Food Bioactives the awesome results of the pioneering study, nether the wide rubric “Quantification of 3,3-dimethyl-1-butanol (DMB) successful olive oil: a accelerated and caller method“.

Until now, nary method had been published that could reliably find successful laboratory the concentrations of this substance successful other virgin olive oil. As the researchers note, this is the archetypal clip that the beingness of the DMB constituent successful olive lipid has been confirmed successful the laboratory, based connected a reliable technological method, and its values ​​have been determined with awesome results.

(Apostolos Kyritsakis)

This probe besides provided a definitive reply to the main question of the planetary technological assemblage of olive oil: whether the bioactive substance DMB really exists successful olive oil.

Based connected the supra publication, the well-known INFORM mag of the American Oil Chemists’ Society (AOCS), successful its October 2025 issue, successful a peculiar nonfiction entitled “Scientists survey a invaluable constituent successful olive oil”, wherever peculiar and extended notation is made to the DMB compound and its relation successful quality health.

(Tassos Kyriakidis)

There, peculiar notation was made of the technological squad that identified this component, led by Professor Emeritus of the IHU, Mr. Apostolos Kyritsakis, Professor Mr. Ahmet Ceyhan Goren of the University of Istanbul, Assistant Professor of School of Public Health of Yale University, Mr. Tassos Kyriakides, arsenic good arsenic the publication and pivotal relation of Sakellaropoulos Organic Farms successful this discovery.

In continuation, Tassos Kyriakides, adjunct prof astatine the School of Public Health of Yale University successful the USA, arsenic good arsenic the technological squad of Mr. Apostolos Kiritsakis and Nikos Sakellaropoulos, are starting a caller collaboration to analyse the relation of the substance DMB (3,3-dimethyl-1-butanol) which was precocious identified successful olive oil, and chiefly the mode it acts against inflammation, cardiac and neurodegenerative diseases, particularly Alzheimer’s, successful the quality body.

(Nikos Sakellaropoulos)

The rubric of this probe effort is “DMB, Gut Microbiota and Heart Health”, portion the main absorption of the probe is the relation of 3,3-dimethyl-1-butanol (DMB) from other virgin olive lipid (EVOO) successful inhibiting the accumulation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) by the intestinal microbiota.

This is the archetypal organized technological effort focused connected this caller compound (DMB), opening caller avenues to survey its relation arsenic good arsenic different bioactive – beneficial components of olive lipid successful quality health.

Research to day has shown that the bioactive substance DMB has a affirmative effect against the harmful compounds trimethylamine (TMA) and trimethylamine N-oxide (TMAO), compounds that are associated with the induction of atherosclerosis, the quality of inflammation successful assorted cardiovascular and neurodegenerative diseases..

Specifically, the harmful substance TMAO is simply a metabolite that depends connected the intestinal microflora, is associated with inflammatory diseases, whose immunological processes bespeak those of rheumatoid arthritis (RA).

Professor of the School of Public Health of Yale University, Mr. Kyriakides, characterizes the substance DMB arsenic precise important and believes that it affects inflammation and consequently cardiovascular and neurodegenerative diseases. He states: “The archetypal extremity of the laboratory probe is to analyse however DMB affects definite compartment lines and the people of cardiovascular and different diseases related to inflammation. We volition commencement from the cells recovered successful the intestinal microbiome to find to what grade DMB acts positively connected the microbiome and prevents the instauration of the undesirable substance TMA, arsenic its inhibitor. Essentially, a technological detection volition beryllium carried retired connected the compartment lines to spot which ones volition payment from DMB and past objective studies volition follow. Personally, I judge that determination is simply a superior anticipation of the health-protective substance DMB besides affecting immune problems, due to the fact that inflammation is besides related to the immune system. For this reason, we volition “screen” bacteria successful the intestinal microbiota due to the fact that each bacterium has a circumstantial mission. If we find the targets of the bacteria, the representation volition go clearer and determination volition beryllium the corresponding technological announcements.”

Professor Emeritus of the International Hellenic University, Mr. Kiritsakis, states that helium is optimistic astir the expected results of the planned survey and believes that DMB volition unfastened caller horizons for this bioactive constituent of olive lipid and volition beryllium the springboard for caller probe and discoveries, arsenic has been done truthful acold with phenols and different microcomponents.

A Memorandum of Understanding has already been signed for this caller probe and study, portion this synergy with Mr. Kyriakides of School of Public Health of Yale University and Professor Emeritus of the International Hellenic University, Mr. Kiritsakis, is based connected the information that successful the archetypal publication, the olive oils by Sakellaropoulos Organic Farms showed systematically precocious concentrations of DMB.

“Scientific research connected the benefits of our olive products, successful collaboration with assemblage institutions, Schools of Public Health and researchers from Medical Schools, specified arsenic Harvard, Yale, Temple and Auburn successful the USA, arsenic good arsenic the Department of Pharmacy of the National and Kapodistrian University of Athens, is astatine the halfway of Sakellaropoulos Organic Farms,” said accumulation manager and chemic technologist M.Sc. Nikos Sakellaropoulos. “Having already participated successful the radical of scientists from galore countries that published for the archetypal clip the caller and innovative method for measuring DMB successful olive oil, we are starting this collaboration with the purpose of highlighting the benefits of the bioactive substance DMB connected quality health. It is simply a peculiar grant for us to enactment successful this benignant of research, the results of which tin amended people’s wellness and consequently their prime of life.”

He besides noted that: “The samples of other virgin olive oils with the highest concentrations, among those analyzed successful the laboratory during the find of the method for determining the bioactive substance DMB, travel exclusively from Sakellaropoulos Organic Farms. More specifically, the adjacent studies and probe volition absorption connected the multi-varietal olive lipid Plus Health DMB EVOO from our integrated farms, successful which precocious concentrations of the substance DMB were detected.”

The archetypal results of the studies are not expected earlier the outpouring of 2026, said prof of Yale School of Public Health, Dr. Tassos Kyriakides. “After we observe the nonstop mechanics of DMB’s relation arsenic an inhibitor of the harmful compounds TMA and TMAO, we volition past determination connected to specialized objective studies. Of course, the results are what volition find the people of the research, arsenic good arsenic the further improvement regarding the benefits for quality health.”